My project focuses on a functional characterisation of the correlation between ankylosing spondylitis (AS) and inflammatory bowel disease (IBD), by analysing the immune cell populations from the bloodstream of patients with AS.
I am investigating the different genes/proteins involved in psoriasis, psoriatic arthritis, ankylosing spondylitis and inflammatory bowel disease. Long term, I aim to discover a scientific measurement/test to stratify patients according to how they will respond to each possible treatment.
Food allergies and inflammatory bowel diseases result from an abnormality in the way the immune system reacts to harmless materials in our gut such as foods and friendly bacteria. The liver drains all the blood coming from the intestine and has long been thought to be important in controlling immune responses to these materials. However, how this works is still unknown. My project aims to study the role of Kupffer cells, the most abundant immune cell in the liver, in this process.
I am investigating how regulatory T cells (Tregs) modulate the effector T cell response during inflammation and in the steady state. Specifically I am interested in the dynamic expression of master transcription factors by Tregs during and after infection with intestinal pathogens.
My PhD project involves analysing samples from patients with alopecia areata. We are analysing the immunophenotype of patients and comparing them with healthy controls to identify changes in immune cell populations that characterise the disease and its link with intestinal inflammation.