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Food allergies and inflammatory bowel diseases result from an abnormality in the way the immune system reacts to harmless materials in our gut such as foods and friendly bacteria. The liver drains all the blood coming from the intestine and has long been thought to be important in controlling immune responses to these materials. However, how this works is still unknown. My project aims to study the role of Kupffer cells, the most abundant immune cell in the liver, in this process.